Scientific and Computational Expertise

Leading multidisciplinary bioinformatics projects, mentoring researchers, and collaborating across biology, chemistry, pharmacology, translational medicine and clinical research.

Interactions between neurons, astrocytes, endothelial cells, mural cells, microglia and the extracellular matrix — blood-brain barrier biology, vascular specialization, neuroinflammation, epilepsy, stroke and cerebral small vessel disease.

Pharmacokinetic interpretation, formulation-supporting analyses, in vitro-to-in vivo translation, and integration of molecular and functional data to support therapeutic decision-making and biomarker development.

Designing and conducting studies using rodent models of neurological and vascular disease — disease induction, phenotypic characterization, tissue analysis. Licensed and certified for surgical procedures on anesthetized rodents.

Microscopy, quantitative image analysis, histopathology, MRI-linked tissue analysis and vascular morphometry — correlating transcriptomic change with tissue architecture and pathological phenotype.

Scalable, reproducible workflows for RNA-seq, targeted sequencing, RNA editing, proteomics, imaging and pathology-linked data — using modern pipelines, statistical analysis, version control, automated reporting and high-performance computing.

Integrating bulk RNA-seq, single-cell RNA-seq, spatial transcriptomics, proteomics, secretomics, imaging, histopathology and public datasets to identify mechanisms, characterize cellular states, prioritize targets and discover biomarkers.

Computational analysis of ADAR-mediated RNA editing: quantifying editing efficiency, evaluating target engagement, characterizing isoform-specific effects, assessing off-target editing and identifying transcriptomic safety signals.