Neurobiology. Bioinformatics. Drug Discovery
Decoding the Neurovascular Unit: From Barrier Biology to Targeted RNA Editing
Neurobiologist with >16 years of experience in academia and industry. Research centers on how glial, vascular, and extracellular-matrix interactions regulate brain homeostasis and disease, with emphasis on epilepsy, stroke and vascular dementia. The work integrates in vivo rodent models, microscopy and single-cell RNA sequencing to define mechanisms, identify therapeutic targets, and support targeted RNA-editing strategies.
The neurovascular unit — where endothelial cells, mural cells, astrocytes, microglia and the extracellular matrix decide whether the brain stays resilient.
About me
I am a neurobiologist with expertise in omics and drug discovery. My work combines bulk and single-cell RNA-seq, RNA editing, and imaging, to understand the neurovascular unit. Across academia, pharma, and biotech, I have focused on one central goal: translating complex biological data into clear, actionable insight. I am fascinated by how the nervous system fails in disease, and how…
Read moreResearch
My academic research focuses on how cells of the brain and vasculature communicate to maintain tissue homeostasis, and how failure of this communication contributes to neurological disease. Across epilepsy, stroke, cerebral small vessel disease, neuroinflammation, and blood-brain barrier dysfunction, I have combined experimental disease models, human tissue analysis, imaging, histopathology, transcriptomics, proteomics, and multi-modal data integration to uncover disease mechanisms and identify translationally relevant biology.
Extracellular matrix instructs vascular identity
Laminin composition in the vascular basement membrane is not merely structural — it actively instructs endothelial identity, mural-cell programs and…
Refining what "neuroinflammation" means in cSVD
Non-amyloid small vessel disease is characterised by microglial activation, focal plasma protein leakage and demyelination — without substantial…
Not loss of protein — redistribution and phosphorylation
Astrocyte uncoupling in epilepsy is not caused by losing connexin43. The protein is redistributed and differently phosphorylated — a post-translational…
Making editing datasets decision-ready
Computational workflows for RNA-editing drug discovery: editing efficiency, target engagement, isoform effects, off-target prediction and transcriptomic…
Vision
Neurological disorders such as stroke, epilepsy, dementia, and cerebral small vessel disease are not only diseases of neurons. They are disorders of the wider neurovascular system that sustains brain function.
BBB dysfunction is not a uniform, capillary-only event — it is segment-specific across arterial, capillary and venous endothelial states.
The BBB is not a static wall but a dynamic sensing interface that responds to circulating metabolites, lipids, hormones, cytokines and…
Using ADAR-recruiting oligonucleotides to recode connexin43 phosphorylation sites — testing whether RNA-level intervention can preserve…
Industry & Translational
My industrial research focuses on using computational biology, pharmacology, and translational data analysis to support therapeutic development. I have worked across RNA-editing therapeutics, bioinformatics platform development…
Read moreTeaching & Mentoring
I have over eight years of teaching and mentoring experience across undergraduate, graduate, and research-training settings. My teaching focuses on helping students move beyond memorization toward scientific reasoning…
Read moreExpertise
Collaboration
Open to collaboration, faculty roles and translational partnerships. If you are working on the neurovascular unit, RNA therapeutics, or a transcriptomics problem that needs a mechanistic reading — I would like to hear about it.
