Neurovascular Unit
Vascular Basement Membrane Laminins
Extracellular matrix instructs vascular identity
In my current role as Senior Scientist and Project Leader for the Bioinformatics Platform at ProQR Therapeutics, I bring a mechanistic and quantitative approach into therapeutic development. I lead transcriptomic and bioinformatics efforts supporting RNA-editing programs for genetic disease, including analyses of target engagement, editing efficiency, isoform effects and off-target risk.
What the work actually delivers
The impact is to make RNA-editing datasets interpretable and decision-ready for discovery teams. I connect molecular readouts with disease biology, mechanism of action, candidate selection, lead prioritization and translational planning.
I design reproducible pipelines, automated reporting workflows and data infrastructure that support decision-making across preclinical programs, while also exploring AI-assisted approaches for predicting editing outcomes and prioritizing lead candidates.
CNS discovery
I support CNS discovery programs in epilepsy, Rett syndrome and Alzheimer's disease by prioritizing oligonucleotide candidates and characterizing disease models — and contributed pharmacodynamic and biological data analyses supporting the investigational new drug application for AX-810 in cholestatic disease.